Each week, Dr. Mark Ebell, POEMs Editor, joins Dr. Michael Wilkes, NPR correspondent and Vice-Dean of the UC-Davis Medical School, for a five minute discussion about an important recent medical study reviewed by the POEMs editors. POEMs provide synopsised reviews of studies that could affect a clinician's practice, and the discussion in this podcast provides additional depth and insight into the issue covered by the POEMs synopsis. More about POEMs and it's companion point-of-care search tool, Essential Evidence Plus, at www.essentialevidenceplus.com.
Episode 677: Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Terbinafine 250 mg once daily — 12 weeks on, 12 weeks off, 4 weeks on — is preferred for onychomycosis in adults '
8/7/2023 • 7 minutes, 43 seconds
Episode 676: Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nearly zero risk of sexually transmitting HIV when viral loads are less than 1000 copies per mL '
7/31/2023 • 5 minutes, 39 seconds
Episode 675: Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Overweight/obese adults with symptomatic COVID-19 treated with metformin are less likely to develop long COVID (COVID-OUT) '
7/24/2023 • 6 minutes, 12 seconds
Episode 674: Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amoxicillin is no more likely to cause rash than any other antibiotic in patients with mononucleosis '
7/17/2023 • 6 minutes, 3 seconds
Episode 673: Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Once-and-done screening colonoscopy has higher rates of adherence than yearly fecal-based blood testing '
7/10/2023 • 6 minutes, 46 seconds
Episode 672: Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early treatment of gestational diabetes is modestly beneficial for neonatal and maternal outcomes '
7/3/2023 • 6 minutes, 7 seconds
Episode 671: Most people tolerate bedtime thiazide diuretics
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Most people tolerate bedtime thiazide diuretics '
6/26/2023 • 6 minutes, 22 seconds
Episode 670: Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Cholesterol-reducer evolocumab associated with a nonsignificant increase in cardiovascular mortality (FOURIER) '
6/19/2023 • 5 minutes, 59 seconds
Episode 669: Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mifepristone effective and safe for the treatment of adenomyosis with pain symptoms '
6/12/2023 • 6 minutes, 9 seconds
Episode 668: Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Direct oral anticoagulants are noninferior to low-molecular-weight heparin to prevent recurrent VTE in adults with cancer '
6/5/2023 • 6 minutes, 19 seconds
Episode 667: Early return to activity improves symptoms in children with concussion
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early return to activity improves symptoms in children with concussion '
5/29/2023 • 4 minutes, 28 seconds
Episode 666: Tailored exercise program improves function and reduces pain due to knee osteoarthritis
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tailored exercise program improves function and reduces pain due to knee osteoarthritis '
5/22/2023 • 6 minutes, 28 seconds
Episode 665: A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' A daily multivitamin has modest impact on memory in older adults (COSMOS-WEB) '
5/15/2023 • 7 minutes, 8 seconds
Episode 664: Older treatments for type 2 diabetes do not affect patient-oriented outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Older treatments for type 2 diabetes do not affect patient-oriented outcomes '
5/8/2023 • 5 minutes, 27 seconds
Episode 663: Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Intravenous hydrocortisone reduces all-cause mortality in severe community-acquired pneumonia (CAPE COD) '
5/1/2023 • 6 minutes, 28 seconds
Episode 662: Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Postexposure prophylaxis with doxycycline in men who have sex with men and transgender women with or at risk of HIV reduces STI risk (NNT = 5) '
4/24/2023 • 7 minutes, 42 seconds
Episode 661: Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Bivalent respiratory syncytial virus (RSV) vaccine given to mothers reduces total and severe RSV infections in infants '
4/17/2023 • 5 minutes, 43 seconds
Episode 660: Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Bempedoic acid 180 mg reduces risk of nonfatal myocardial infarction and revascularization; NNT = 42 in primary prevention group (CLEAR) '
4/10/2023 • 9 minutes, 42 seconds
Episode 659: Discectomy for sciatica provides short-term relief for leg pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Discectomy for sciatica provides short-term relief for leg pain '
4/3/2023 • 7 minutes, 44 seconds
Episode 658: Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Active surveillance reduces the need for surgery, with no change in mortality, at the price of a small increase of metastatic disease (ProtecT) '
3/27/2023 • 7 minutes, 26 seconds
Episode 657: Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND) '
3/20/2023 • 6 minutes, 41 seconds
Episode 656: Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain '
3/13/2023 • 4 minutes, 59 seconds
Episode 655: Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9) '
3/6/2023 • 6 minutes, 33 seconds
Episode 654: Brief behavioral therapy improves sleep in older adults with chronic insomnia
Dr. Ebell and Dr. Wilkes discuss the POEM titled 'Brief behavioral therapy improves sleep in older adults with chronic insomnia '
2/27/2023 • 4 minutes, 31 seconds
Episode 653: Brief behavioral therapy improves sleep in older adults with chronic insomnia
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brief behavioral therapy diminishes insomnia in the elderly '
2/20/2023 • 5 minutes, 54 seconds
Episode 652: Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder '
2/13/2023 • 7 minutes, 16 seconds
Episode 651: No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF) '
2/6/2023 • 5 minutes, 27 seconds
Episode 650: Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients '
1/30/2023 • 8 minutes, 38 seconds
Episode 649: Chlorthalidone no better than hydrochlorothiazide for hypertension
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Chlorthalidone no better than hydrochlorothiazide for hypertension '
1/23/2023 • 6 minutes, 26 seconds
Episode 648: Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT) '
1/16/2023 • 6 minutes, 34 seconds
Episode 647: Tell patients their new knee won't wear out sooner with hard use
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tell patients their new knee won't wear out sooner with hard use '
1/9/2023 • 7 minutes, 33 seconds
Episode 646: Majority of CIN2 regress in women aged 25 to 30 years
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Majority of CIN2 regress in women aged 25 to 30 years '
1/2/2023 • 6 minutes, 8 seconds
Episode 645: Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME) '
12/26/2022 • 5 minutes
Episode 644: Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes '
12/19/2022 • 7 minutes, 8 seconds
Episode 643: Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC)
Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC) '
